Laboratory Reference Intervals for Routinely Analyzed Transferrin and Unsaturated Iron-Binding Capacity Parameters in the Adult Population of Uasin Gishu County, Kenya

Willington Kasimu; Gitonga Godfrey; Ezra Osoro; Anne Wanjiku; James Mbithi Mulinge

doi:10.51867/ajernet.6.1.58

Autores

Willington Kasimu Department of Medical Laboratory Sciences, School of Public Health Biomedical Sciences and Technology, Masinde Muliro University of Science and Technology, P.O. Box 190-50100 Kakamega, Kenya https://orcid.org/0009-0009-5809-1922
Gitonga Godfrey Department of Medical Laboratory Sciences, School of Public Health Biomedical Sciences and Technology, Masinde Muliro University of Science and Technology, P.O. Box 190-50100 Kakamega, Kenya https://orcid.org/0000-0003-1891-1817
Ezra Osoro Department of Medical Biochemistry, Masinde Muliro University of Science and Technology, P.O. Box 190-50100 Kakamega, Kenya https://orcid.org/0000-0001-6565-5911
Anne Wanjiku Directorate of Laboratory and Pathology Services, Moi Teaching and Referral Hospital, P.O. Box 3 - 30100 Eldoret, Kenya
James Mbithi Mulinge Department of Medical Biochemistry, Masinde Muliro University of Science and Technology, P.O. Box 190-50100 Kakamega, Kenya https://orcid.org/0000-0002-2987-3724

DOI:

https://doi.org/10.51867/ajernet.6.1.58

Palavras-chave:

Healthy Population, Reference Intervals, Transferrin, Unsaturated Iron Binding Capacity, Uasin Gishu, Kenya

Resumo

Reference intervals (RIs) are used in the interpretation of clinical laboratory data to help doctors reach a medical decision point. However, due to a variety of reasons, RIs varies significantly between various populations. This study aimed at establishing transferrin, and IUBC reference intervals that can be used locally for the interpretation of iron indices at MTRH. A cross sectional study was conducted at Moi Teaching and Referral Hospital, 290 healthy volunteers were enrolled in the study where their transferrin and IUBC were examined. The non-parametric approach was used to determine reference values with a 95% confidence interval. The Sigma diagnostics approach was used to verify the established Ris. IBM SPSS version 23.0 was used to conduct the statistical analysis. Mann-Whitney U tests were used to compare genders for significant differences. The established reference intervals for Transferrin: males: 2.13–4.01 g/L, females, 2.08–4.04 g/L; UIBC: males, 20.50–64.08 umol/L, females: 20.07–64.21 umol/L. Comparisons between genders for significant differences were done using Mann-Whitney U tests, revealing no significant gender-based differences between transferrin and UIBC exhibited. The established reference intervals in this study are age and sex-specific for routinely used transferrin and IUBC catering for the adult population of Uasin Gishu County aged 18–64 years. The result will assist the clinicians in reaching an informed medical decision.

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